[Nome del progetto]

1. Miglione A., Raucci A., Amato J., Marzano S., Pagano B., Raia T., Lucarelli M., Fuso A., Cinti S. "Printed electrochemical strip for the detection of miRNA-29a: a possible biomarker related to Alzheimer's disease" Anal. Chem. 2022, 10.1021/acs.analchem.2c03542

2. Riccardi C., D'Aria F., Fasano D., Digilio F.A., Carillo M.R., Amato J., De Rosa L., Paladino S., Melone M.A.B., Montesarchio D., Giancola C. "Truncated analogues of a G-quadruplex-forming aptamer targeting mutant Huntingtin: shorter is better!" Int. J. Mol. Sci. 2022, 10.3390/ijms232012412

3. Moraca F., Marzano S., D'Amico F., Lupia A., Di Fonzo S., Vertecchi E., Salvati E., Di Porzio A., Catalanotti B., Randazzo A., Pagano B., Amato J. "Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders" Chem. Commun. 2022, 10.1039/d2cc03135c

4. Marzano S., Miglietta G., Morigi R., Marinello J., Arleo A., Procacci M., Locatelli A., Leoni A., Pagano B., Randazzo A., Amato J., Capranico G. "Balancing affinity, selectivity, and cytotoxicity of hydrazone-based G-quadruplex ligands for activation of interferon-β genes in cancer cells" J. Med. Chem. 2022, 10.1021/acs.jmedchem.2c00772

5. Napolitano F., Di Somma S., Castellano G., Amato J., Pagano B., Randazzo A., Portella G., Malfitano A.M. "Combination of dl922-947 oncolytic adenovirus and G-quadruplex binders uncovers improved antitumor activity in breast cancer" Cells 2022, 10.3390/cells11162482

6. Chianese U., Papulino C., Passaro E., Evers T.M., Babaei M., Toraldo A., De Marchi T., Niméus E., Carafa V., Nicoletti M.M., Del Gaudio N., Iaccarino N., Randazzo A., Rotili D., Mai A., Cappabianca S., Mashaghi A., Ciardiello F., Altucci L., Benedetti R. "Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics" Mol. Metab. 2022, 10.1016/j.molmet.2022.101561

7. Riccardi C., Piccolo M., Ferraro M.G., Graziano R., Musumeci D., Trifuoggi M., Irace C., Montesarchio D. "Bioengineered lipophilic Ru(III) complexes as potential anticancer agents" Biomater Adv. 2022, 10.1016/j.bioadv.2022.213016

8. Riccardi C., D'Aria F., Digilio F.A., Carillo M.R., Amato J., Fasano D., De Rosa L., Paladino S., Melone M.A.B., Montesarchio D., Giancola C. "Fighting the Huntington's disease with a G-quadruplex-forming aptamer specifically binding to mutant Huntingtin protein: biophysical characterization, in vitro and in vivo studies" Int. J. Mol. Sci. 2022, 10.3390/ijms23094804

9. Amato J., Iaccarino N., D'Aria F., D'Amico F., Randazzo A., Giancola C., Cesàro A., Di Fonzo S., Pagano B. "Conformational plasticity of DNA secondary structures: probing the conversion between i-motif and hairpin species by circular dichroism and ultraviolet resonance Raman spectroscopies" Phys. Chem. Chem. Phys. 2022, 10.1039/d2cp00058j

10. Minenkova O., Santapaola D., Milazzo F.M., Anastasi A.M., Battistuzzi G., Chiapparino C., Rosi A., Gritti G., Borleri G., Rambaldi A., Dental C., Viollet C., Pagano B., Salvini L., Marra E., Luberto L., Rossi A., Riccio A., Merlo Pich E., Santoro M.G., De Santis R. "Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy" Mol. Ther. 2022, 10.1016/j.ymthe.2022.02.013

11. Russo C., Amato J., Tron G.C., Giustiniano M. "The dark side of isocyanides: visible-light photocatalytic activity in the oxidative functionalization of C(sp(3))-H bonds" J. Org. Chem. 2021, 10.1021/acs.joc.1c02378

12. Di Porzio A., Galli U., Amato J., Zizza P., Iachettini S., Iaccarino N., Marzano S., Santoro F., Brancaccio D., Carotenuto A., De Tito S., Biroccio A., Pagano B., Tron G.C., Randazzo A. "Synthesis and characterization of bis-triazolyl-pyridine derivatives as noncanonical DNA-interacting compounds" Int. J. Mol. Sci. 2021, 10.3390/ijms222111959

13. Platella C., Ghirga F., Zizza P., Pompili L., Marzano S., Pagano B., Quaglio D., Vergine V., Cammarone S., Botta B., Biroccio A., Mori M., Montesarchio D. "Identification of effective anticancer G-quadruplex-targeting chemotypes through the exploration of a high diversity library of natural compounds" Pharmaceutics 2021, 10.3390/pharmaceutics13101611

14. Russomanno P., Assoni G., Amato J., D'Amore V.M., Scaglia R., Brancaccio D., Pedrini M., Polcaro G., La Pietra V., Orlando P., Falzoni M., Cerofolini L., Giuntini S., Fragai M., Pagano B., Donati G., Novellino E., Quintavalle C., Condorelli G., Sabbatino F., Seneci P., Arosio D., Pepe S., Marinelli L. "Interfering with the tumor-immune interface: making way for triazine-based small molecules as novel PD-L1 inhibitors" J. Med. Chem. 2021, 10.1021/acs.jmedchem.1c01409

15. Marzano S., Pagano B., Iaccarino N., Di Porzio A., De Tito S., Vertecchi E., Salvati E., Randazzo A., Amato J. "Targeting of telomeric repeat-containing RNA G-quadruplexes: from screening to biophysical and biological characterization of a new hit compound" Int. J. Mol. Sci. 2021, 10.3390/ijms221910315

16. Vranas M., Wohlwend D., Qiu D., Gerhardt S., Trncik C., Pervaiz M., Ritter K., Steimle S., Randazzo A., Einsle O., Günther S., Jessen H.J., Kotlyar A., Friedrich T. "Structural basis for inhibition of ROS-producing respiratory complex I by NADH-OH" Angew. Chem. Int. Ed. Engl. 2021, 10.1002/anie.202112165

17. Usacheva T.R., Volynkin V.A., Panyushkin V.T., Lindt D.A., Pham T.L., Nguyen T.T.H., Le T.M.H., Alister D.A., Kabirov D.N., Kuranova N.N., Gamov G.A., Kushnir R.A., Biondi M., Giancola C., Sharnin V.A. "Complexation of cyclodextrins with benzoic acid in water-organic solvents: a solvation-thermodynamic approach" Molecules 2021, 10.3390/molecules26154408

18. Venturi S., Randazzo A., Tassi F., Gioli B., Buccianti A., Gualtieri G., Capecchiacci F., Cabassi J., Brilli L., Carotenuto F., Santi R., Vagnoli C., Zaldei A., Vaselli O. "Unveiling the changes in urban atmospheric CO(2) in the time of COVID-19 pandemic: a case study of Florence (Italy)" Sci. Total. Environ. 2021, 10.1016/j.scitotenv.2021.148877

19. Amato J., D'Aria F., Marzano S., Iaccarino N., Randazzo A., Giancola C., Pagano B. "On the thermodynamics of folding of an i-motif DNA in solution under favorable conditions" Phys. Chem. Chem. Phys. 2021, 10.1039/d1cp01779a

20. Tomassi S., D'Amore V.M., Di Leva F.S., Vannini A., Quilici G., Weinmüller M., Reichart F., Amato J., Romano B., Izzo A.A., Di Maro S., Novellino E., Musco G., Gianni T., Kessler H., Marinelli L. "Halting the spread of Herpes Simplex Virus-1: the discovery of an effective dual αvβ6/αvβ8 Integrin ligand" J. Med. Chem. 2021, 10.1021/acs.jmedchem.1c00533

21. Stefanucci A., Amato J., Brancaccio D., Pagano B., Randazzo A., Santoro F., Mayol L., Learte-Aymamí S., Rodriguez J., Mascareñas J.L., Novellino E., Carotenuto A., Mollica A. "A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA" Bioorg. Chem. 2021, 10.1016/j.bioorg.2021.104836

22. Horchani M., Della Sala G., Caso A., D'Aria F., Esposito G., Laurenzana I., Giancola C., Costantino V., Jannet H.B., Romdhane A. "Molecular docking and biophysical studies for antiproliferative assessment of synthetic pyrazolo-pyrimidinones tethered with hydrazide-hydrazones" Int. J. Mol. Sci. 2021, 10.3390/ijms22052742

23. Iaccarino N., Cheng M., Qiu D., Pagano B., Amato J., Di Porzio A., Zhou J., Randazzo A., Mergny J.L. "Effects of sequence and base composition on the CD and TDS profiles of i-DNA" Angew. Chem. Int. Ed. Engl. 2021, 10.1002/anie.202016822

24. Daniele S., La Pietra V., Piccarducci R., Pietrobono D., Cavallini C., D'Amore V.M., Cerofolini L., Giuntini S., Russomanno P., Puxeddu M., Nalli M., Pedrini M., Fragai M., Luchinat C., Novellino E., Taliani S., La Regina G., Silvestri R., Martini C., Marinelli L. "CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme" Eur J Pharmacol. 2021, 10.1016/j.ejphar.2021.173936

25. D'Aria F., Pagano B., Petraccone L., Giancola C. "KRAS promoter G-quadruplexes from sequences of different length: a physicochemical study" Int. J. Mol. Sci. 2021, 10.3390/ijms22010448

26. Pirota V., Platella C., Musumeci D., Benassi A., Amato J., Pagano B., Colombo G., Freccero M., Doria F., Montesarchio D. "On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model" Int. J. Biol. Macromol. 2021, 10.1016/j.ijbiomac.2020.11.013

27. Ogloblina A.M., Iaccarino N., Capasso D., Di Gaetano S., Garzarella E.U., Dolinnaya N.G., Yakubovskaya M.G., Pagano B., Amato J., Randazzo A. "Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives" Int J Mol Sci. 2020, 10.3390/ijms21207781

28. Cannalire R., Amato J., Summa V., Novellino E., Tron G.C., Giustiniano M. "Visible-light photocatalytic functionalization of isocyanides for the synthesis of secondary amides and ketene aminals" J. Org. Chem. 2020, 10.1021/acs.joc.0c01946

29. Amato J., Mashima T., Kamatari Y.O., Kuwata K., Novellino E., Randazzo A., Giancola C., Katahira M., Pagano B. "Improved anti-prion nucleic acid aptamers by incorporation of chemical modifications" Nucleic Acid. Ther. 2020, 10.1089/nat.2020.0899

30. Minard A., Morgan D., Raguseo F., Di Porzio A., Liano D., Jamieson A.G., Di Antonio M. "A short peptide that preferentially binds c-MYC G-quadruplex DNA" Chem. Commun. 2020, 10.1039/d0cc02954h

31. Gütschow M., Eynde J.J.V., Jampilek J., Kang C., Mangoni A.A., Fossa P., Karaman R., Trabocchi A., Scott P.J.H., Reynisson J., Rapposelli S., Galdiero S., Winum J.Y., Brullo C., Prokai-Tatrai K., Sharma A.K., Schapira M., Azuma Y.T., Cerchia L., Spetea M., Torri G., Collina S., Geronikaki A., García-Sosa A.T., Vasconcelos M.H., Sousa M.E., Kosalec I., Tuccinardi T., Duarte I.F., Salvador J.A.R., Bertinaria M., Pellecchia M., Amato J., Rastelli G., Gomes P.A.C., Guedes R.C., Sabatier J.M., Estévez-Braun A., Pagano B., Mangani S., Ragno R., Kokotos G., Brindisi M., González F.V., Borges F., Miloso M., Rautio J., Muñoz-Torrero D. "Breakthroughs in medicinal chemistry: new targets and mechanisms, new drugs, new hopes-7" Molecules 2020, 10.3390/molecules25132968

32. Brancaccio D., Di Maro S., Cerofolini L., Giuntini S., Fragai M., Luchinat C., Tomassi S., Limatola A., Russomanno P., Merlino F., Novellino E., Carotenuto A. "HOPPI-NMR: hot-peptide-based screening assay for inhibitors of protein-protein interactions by NMR" ACS Med. Chem. Lett. 2020, 10.1021/acsmedchemlett.9b00620

33. Di Francia R., Crisci S., Muto T., Giancola C., Petriccone L., Catapano O., Cummarro A., Pinto A., Frigeri F. "Optimization of a low-cost, sensitive PNA clamping PCR method for JAK2 V617F variant detection" J. Appl. Lab. Med. 2020, 10.1093/jalm/jfaa041

34. D'Aria F., D'Amore V.M., Di Leva F.S., Amato J., Caterino M., Russomanno P., Salerno S., Barresi E., De Leo M., Marini A.M., Taliani S., Da Settimo F., Salgado G.F., Pompili L., Zizza P., Shirasawa S., Novellino E., Biroccio A., Marinelli L., Giancola C. "Targeting the KRAS oncogene: synthesis, physicochemical and biological evaluation of novel G-quadruplex DNA binders" Eur. J. Pharm. Sci. 2020, 10.1016/j.ejps.2020.105337

35. Musio B., Ragone R., Todisco S., Rizzuti A., Latronico M., Mastrorilli P., Pontrelli S., Intini N., Scapicchio P., Triggiani M., Di Noia T., Acquotti D., Airoldi C., Assfalg M., Barge A., Bateman L., Benevelli F., Bertelli D., Bertocchi F., Bieliauskas A., Borioni A., Caligiani A., Callone E., Čamra A., Cesare Marincola F., Chalasani D., Consonni R., Dambruoso P., Davalli S., David T., Diehl B., Donarski J., Gil A.M., Gobetto R., Goldoni L., Hamon E., Harwood J.S., Kobrlová A., Longobardi F., Luisi R., Mallamace D., Mammi S., Martin-Biran M., Mazzei P., Mele A., Milone S., Molero Vilchez D., Mulder R.J., Napoli C., Ragno D., Randazzo A., Rossi M.C., Rotondo A., Šačkus A., Sáez Barajas E., Schievano E., Sitaram B., Stevanato L., Takis P.G., Teipel J., Thomas F., Torregiani E., Valensin D., Veronesi M., Warren J., Wist J., Zailer-Hafer E., Zuccaccia C., Gallo V. "A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy" Talanta 2020, 10.1016/j.talanta.2020.120855

36. Di Fonzo S., Amato J., D'Aria F., Caterino M., D'Amico F., Gessini A., Brady J.W., Cesàro A., Pagano B., Giancola C. "Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy" Phys. Chem. Chem. Phys. 2020, 10.1039/d0cp01022g

37. Amato J., Miglietta G., Morigi R., Iaccarino N., Locatelli A., Leoni A., Novellino E., Pagano B., Capranico G., Randazzo A. "Monohydrazone based G-quadruplex selective ligands induce DNA Damage and Genome Instability in Human Cancer Cells" J. Med. Chem. 2020, 10.1021/acs.jmedchem.9b01866

38. Rocca R., Palazzesi F., Amato J., Costa G., Ortuso F., Pagano B., Randazzo A., Novellino E., Alcaro S., Moraca F., Artese A. "Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics" Sci. Rep. 2020, 10.1038/s41598-020-59774-x

39. Caterino M., D'Aria F., Kustov A.V., Belykh D.V., Khudyaeva I.S., Starseva O.M., Berezin D.B., Pylina Y.I., Usacheva T., Amato J., Giancola C. "Selective binding of a bioactive porphyrin-based photosensitizer to the G-quadruplex from the KRAS oncogene promoter" Int. J. Biol. Macromol. 2020, 10.1016/j.ijbiomac.2019.12.152

40. Iaccarino N., Khakimov B., Mikkelsen M.S., Nielsen T.S., Jensen M.G., Randazzo A., Engelsen S.B. "Structurally different mixed linkage β-glucan supplements differentially increase secondary bile acid excretion in hypercholesterolaemic rat faeces" Food Funct. 2020, 10.1039/c8fo02507j

41. Di Somma S., Amato J., Iaccarino N., Pagano B., Randazzo A., Portella G., Malfitano A.M. "G-quadruplex binders induce immunogenic cell death markers in aggressive breast cancer cells" Cancers 2019, 10.3390/cancers11111797

42. Pagano B., Iaccarino N., Di Porzio A., Randazzo A., Amato J. "Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry" Analyst 2019, 10.1039/c9an01463b

43. Iaccarino N., Di Porzio A., Amato J., Pagano B., Brancaccio D., Novellino E., Leardi R., Randazzo A. "Assessing the influence of pH and cationic strength on i-motif DNA structure" Anal. Bioanal. Chem. 2019, 10.1007/s00216-019-02120-6

44. De Simone A., La Pietra V., Betari N., Petragnani N., Conte M., Daniele S., Pietrobono D., Martini C., Petralla S., Casadei R., Davani L., Frabetti F., Russomanno P., Novellino E., Montanari S., Tumiatti V., Ballerini P., Sarno F., Nebbioso A., Altucci L., Monti B., Andrisano V., Milelli A. "Discovery of the first-in-class GSK-3β/HDAC dual inhibitor as disease-modifying agent to combat alzheimer's disease" ACS Med. Chem. Lett. 2019, 10.1021/acsmedchemlett.9b00316

45. Amato J., Cerofolini L., Brancaccio D., Giuntini S., Iaccarino N., Zizza P., Iachettini S., Biroccio A., Novellino E., Rosato A., Fragai M., Luchinat C., Randazzo A., Pagano B. "Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein" Nucleic Acids Res. 2019, 10.1093/nar/gkz727

46. Catalano R., Moraca F., Amato J., Cristofari C., Rigo R., Via L.D., Rocca R., Lupia A., Maruca A., Costa G., Catalanotti B., Artese A., Pagano B., Randazzo A., Sissi C., Novellino E., Alcaro S. "Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives" Eur. J. Med. Chem. 2019, 10.1016/j.ejmech.2019.111627

47. Iaccarino N., Varming C., Agerlin Petersen M., Viereck N., Schütz B., Toldam-Andersen T.B., Randazzo A., Balling Engelsen S. "Ancient danish apple cultivars-A comprehensive metabolite and sensory profiling of apple juices" Metabolites 2019, 10.3390/metabo9070139

48. Pelliccia S., Amato J., Capasso D., Di Gaetano S., Massarotti A., Piccolo M., Irace C., Tron G.C., Pagano B., Randazzo A., Novellino E., Giustiniano M. "Bio-inspired dual-selective BCL-2/c-MYC G-quadruplex binders: design, synthesis, and anticancer activity of drug-like imidazo[2,1-i]purine derivatives" J. Med. Chem. 2020, 10.1021/acs.jmedchem.9b00262

49. Di Carluccio C., Crisman E., Manabe Y., Forgione R.E., Lacetera A., Amato J., Pagano B., Randazzo A., Zampella A., Lanzetta R., Fukase K., Molinaro A., Crocker P.R., Martín-Santamaría S., Marchetti R., Silipo A. "Characterisation of the dynamic interactions between complex N-glycans and human CD22" ChemBioChem. 2020, 10.1002/cbic.201900295

50. Iaccarino N., Amato J., Pagano B., Di Porzio A., Micucci M., Bolelli L., Aldini R., Novellino E., Budriesi R., Randazzo A. "Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study" J. Enzyme Inhib. Med. Chem. 2019 10.1080/14756366.2019.1611802

51. Khristenko N., Amato J., Livet S., Pagano B., Randazzo A., Gabelica V. "Native ion mobility mass spectrometry: when gas-phase ion structures depend on the electrospray charging process" J. Am. Soc. Mass Spectrom. 2019, 10.1007/s13361-019-02152-3

52. Di Fonzo S., Bottari C., Brady J.W., Tavagnacco L., Caterino M., Petraccone L., Amato J., Giancola C., Cesàro A. "Crowding and conformation interplay on human DNA G-quadruplex by ultraviolet resonant Raman scattering" Phys. Chem. Chem. Phys. 2019, 10.1039/c8cp04728f

53. Cruz-Gallardo I., Martino L., Trotta R., De Tito S., Kelly G., Atkinson R.A., Randazzo A., Conte M.R. "Resonance assignment of human LARP4A La module" Biomol. NMR Assign. 2019, 10.1007/s12104-019-09871-4

54. Amato J., Platella C., Iachettini S., Zizza P., Musumeci D., Cosconati S., Pagano A., Novellino E., Biroccio A., Randazzo A., Pagano B,, Montesarchio D. "Tailoring a lead-like compound targeting multiple G-quadruplex structures" Eur. J. Med. Chem. 2019, 10.1016/j.ejmech.2018.11.058

55. Pagano A., Iaccarino N., Abdelhamid M.A.S., Brancaccio D., Garzarella E.U., Di Porzio A., Novellino E., Waller Z.A.E., Pagano B., Amato J., Randazzo A. "Common G-quadruplex binding agents found to interact with i-Motif-forming DNA: unexpected multi-target-directed compounds" Front. Chem. 2018, 10.3389/fchem.2018.00281

56. Amato J., Madanayake T.W., Iaccarino N., Novellino E., Randazzo A., Hurley L.H., Pagano B. "HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?" Chem. Commun. 2018, 10.1039/c8cc03614d

57. Platella C., Musumeci D., Arciello A., Doria F., Freccero M., Randazzo A., Amato J., Pagano B., Montesarchio D. "Controlled pore glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands" Anal Chim Acta 2018, 10.1016/j.aca.2018.04.071

58. Caterino M., Squillaro T., Montesarchio D., Giordano A., Giancola C., Melone M.A.B. "Huntingtin protein: a new option for fixing the Huntington's disease countdown clock" Neuropharmacology 2018, 10.1016/j.neuropharm.2018.03.009

59. Amato J., Pagano A., Capasso D., Di Gaetano S., Giustiniano M., Novellino E., Randazzo A., Pagano B. "Targeting the BCL2 gene promoter G-quadruplex with a new class of furopyridazinone-based molecules" ChemMedChem. 2018, 10.1002/cmdc.201700749

60. Pagano B., Caterino M., Filosa R., Giancola C. "Binding of harmine derivatives to DNA: a spectroscopic investigation" Molecules 2017, 10.3390/molecules22111831

61. Laezza A., Casillo A., Cosconati S., Biggs C.I., Fabozzi A., Paduano L., Iadonisi A., Novellino E., Gibson M.I., Randazzo A., Corsaro M.M., Bedini E. "Decoration of chondroitin polysaccharide with threonine: synthesis, conformational study, and ice-recrystallization inhibition activity" Biomacromolecules 2017, 10.1021/acs.biomac.7b00326

62. Giancola C., Montesarchio D. "Not unusual, just different! Chemistry, biology and applications of G-quadruplex nucleic acids" Biochim. Biophys. Acta Gen. Subj. 2017, 10.1016/j.bbagen.2017.03.022

63. Salvati E., Botta L., Amato J., Di Leva F.S., Zizza P., Gioiello A., Pagano B., Graziani G., Tarsounas M., Randazzo A., Novellino E., Biroccio A., Cosconati S. "Lead discovery of dual G-quadruplex stabilizers and poly(ADP-ribose) polymerases (PARPs) inhibitors: a new avenue in anticancer treatment" J. Med. Chem. 2017, 10.1021/acs.jmedchem.6b01563

64. Moraca F., Amato J., Ortuso F., Artese A., Pagano B., Novellino E., Alcaro S., Parrinello M., Limongelli V. "Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations" Proc. Natl. Acad. Sci. U.S.A. 2017, 10.1073/pnas.1612627114

65. Gajarský M., Živković M.L., Stadlbauer P., Pagano B., Fiala R., Amato J., Tomáška L., Šponer J., Plavec J., Trantírek L. "Structure of a stable G-hairpin" J. Am. Chem. Soc. 2017, 10.1021/jacs.6b10786

66. Musumeci D., Amato J., Zizza P., Platella C., Cosconati S., Cingolani C., Biroccio A., Novellino E., Randazzo A., Giancola C., Pagano B., Montesarchio D. "Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes" Biochim. Biophys. Acta Gen. Subj. 2017, 10.1016/j.bbagen.2017.01.024

67. Casillo A., Parrilli E., Sannino F., Mitchell D.E., Gibson M.I., Marino G., Lanzetta R., Parrilli M., Cosconati S., Novellino E., Randazzo A., Tutino M.L., Corsaro M.M. "Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection" Carbohydr. Polym. 2017, 10.1016/j.carbpol.2016.09.037

68. Amato J., Pagano A., Cosconati S., Amendola G., Fotticchia I., Iaccarino N., Marinello J., De Magis A., Capranico G., Novellino E., Pagano B., Randazzo A. "Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?" Biochim. Biophys. Acta Gen. Subj. 2017, 10.1016/j.bbagen.2016.11.008

69. Giustiniano M., Pelliccia S., Galli U., Amato J., Travagin F., Novellino E., Tron G.C. "A successful replacement of phenols with isocyanides in the Bargellini reaction: synthesis of 3-carboxamido-isobutyric acids" J. Org. Chem. 2016, 10.1021/acs.joc.6b02130

70. Terzidis M.A., Prisecaru A., Molphy Z., Barron N., Randazzo A., Dumont E., Krokidis M.G., Kellett A., Chatgilialoglu C. "Radical-induced purine lesion formation is dependent on DNA helical topology" Free Radic. Res. 2016, 10.1080/10715762.2016.1244820

71. Amato J., Morigi R., Pagano B., Pagano A., Ohnmacht S., De Magis A., Tiang Y.P., Capranico G., Locatelli A., Graziadio A., Leoni A., Rambaldi M., Novellino E., Neidle S., Randazzo A. "Toward the development of specific G-quadruplex binders: synthesis, biophysical, and biological studies of new hydrazone derivatives" J. Med. Chem. 2016, 10.1021/acs.jmedchem.6b00129

72. Raimondo L., D'Amato V., Servetto A., Rosa R., Marciano R., Formisano L., Di Mauro C., Orsini R.C., Cascetta P., Ciciola P., De Maio A.P., Di Renzo M.F., Cosconati S., Bruno A., Randazzo A., Napolitano F., Montuori N., Veneziani B.M., De Placido S., Bianco R. "Everolimus induces Met inactivation by disrupting the FKBP12/Met complex" Oncotarget 2016, 10.18632/oncotarget.9484

73. Fotticchia I., Guarnieri D., Fotticchia T., Falanga A.P., Vecchione R., Giancola C., Netti P.A. "Energetics of ligand-receptor binding affinity on endothelial cells: an in vitro model" Colloids Surf. B. Biointerfaces 2016, 10.1016/j.colsurfb.2016.04.018

74. Conte C., Fotticchia I., Tirino P., Moret F., Pagano B., Gref R., Ungaro F., Reddi E., Giancola C., Quaglia F. "Cyclodextrin-assisted assembly of PEGylated polyester nanoparticles decorated with folate" Colloids Surf. B. Biointerfaces 2016, 10.1016/j.colsurfb.2016.01.035

75. Lauri I., Savorani F., Iaccarino N., Zizza P., Pavone L.M., Novellino E., Engelsen S.B., Randazzo A. "Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs" Metabolites 2016, 10.3390/metabo6010004

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Zizza P, Cingolani C, Artuso S, Salvati E, Rizzo A, D'Angelo C, Porru M, Pagano B, Amato J, Randazzo A, Novellino E, Stoppacciaro A, Gilson E, Stassi G, Leonetti C, Biroccio A.

Nucleic Acids Res

2016

30/10/15

10.1093/nar/gkv1122

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

Formisano L, D'Amato V, Servetto A, Brillante S, Raimondo L, Di Mauro C, Marciano R, Orsini RC, Cosconati S, Randazzo A, Parsons SJ, Montuori N, Veneziani BM, De Placido S, Rosa R, Bianco R.

Oncotarget

2015

02/09/15

10.18632/oncotarget.4636

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

Giustiniano M, Mercalli V, Amato J, Novellino E, Tron GC.

Org Lett

2015

06/08/15

10.1021/acs.orglett.5b01798

Novel stilbenoids, including cannabispiradienone glycosides, from Tragopogon tommasinii (Asteraceae, Cichorieae) and their potential anti-inflammatory activity

Granica S, Piwowarski JP, Randazzo A, Schneider P, Żyżyńska-Granica B, Zidorn C.

Phytochemistry

2015

24/06/15

10.1016/j.phytochem.2015.06.018

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures

Virgilio A, Esposito V, Mayol L, Giancola C, Petraccone L, Galeone A.

Org Biomol Chem

2015

23/05/15

10.1039/c5ob00748h

Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules

Pagano B, Amato J, Iaccarino N, Cingolani C, Zizza P, Biroccio A, Novellino E, Randazzo A.

ChemMedChem

2015

20/02/15

10.1002/cmdc.201402552

Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands

Cerofolini L, Amato J, Borsi V, Pagano B, Randazzo A, Fragai M.

J Mol Recognit

2015

20/02/15

10.1002/jmr.2452

Identification of novel interactors of human telomeric G-quadruplex DNA

Pagano B, Margarucci L, Zizza P, Amato J, Iaccarino N, Cassiano C, Salvati E, Novellino E, Biroccio A, Casapullo A, Randazzo A.

Chem Commun (Camb)

2015

17/01/15

10.1039/c4cc07231f

A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins

Carillo S, Casillo A, Pieretti G, Parrilli E, Sannino F, Bayer-Giraldi M, Cosconati S, Novellino E, Ewert M, Deming JW, Lanzetta R, Marino G, Parrilli M, Randazzo A, Tutino ML, Corsaro MM.

J Am Chem Soc

2015

20/12/14

10.1021/ja5075954

Thermodynamic signature of secondary nano-emulsion formation by isothermal titration calorimetry

Fotticchia I, Fotticchia T, Mattia CA, Netti PA, Vecchione R, Giancola C.

Langmuir

2014

15/11/14

10.1021/la503558w

Shading the TRF2 recruiting function: a new horizon in drug development

Di Maro S, Zizza P, Salvati E, De Luca V, Capasso C, Fotticchia I, Pagano B, Marinelli L, Gilson E, Novellino E, Cosconati S, Biroccio A.

J Am Chem Soc

2014

14/11/14

10.1021/ja5080773

G-triplex structure and formation propensity

Cerofolini L, Amato J, Giachetti A, Limongelli V, Novellino E, Parrinello M, Fragai M, Randazzo A, Luchinat C.

Nucleic Acids Res

2014

08/11/14

10.1093/nar/gku1084

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex

Amato J, Iaccarino N, Pagano B, Morigi R, Locatelli A, Leoni A, Rambaldi M, Zizza P, Biroccio A, Novellino E, Randazzo A.

Front Chem

2014

09/08/14

10.3389/fchem.2014.00054

Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif

Amato J, Iaccarino N, Randazzo A, Novellino E, Pagano B.

ChemMedChem

2014

26/06/14

10.1002/cmdc.201402153

G-quadruplex on oligo affinity support (G4-OAS): an easy affinity chromatography-based assay for the screening of G-quadruplex ligands

Musumeci D, Amato J, Randazzo A, Novellino E, Giancola C, Montesarchio D, Pagano B.

Anal Chem

2014

15/04/14

10.1021/ac500444m

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex

Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F.

Acta Crystallogr D Biol Crystallogr

2014

18/02/14

10.1107/S1399004713028095

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A.

Nucleic Acids Res

2014

17/12/13

10.1093/nar/gkt1289

Identification of palytoxin-Ca2+ complex by NMR and molecular modeling techniques

Ciminiello P, Dell'Aversano C, Dello Iacovo E, Forino M, Randazzo A, Tartaglione L.

J Org Chem

2014

17/12/13

10.1021/jo4022953

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes

D'Atri V, Borbone N, Amato J, Gabelica V, D'Errico S, Piccialli G, Mayol L, Oliviero G.

Biochimie

2014

10/12/13

10.1016/j.biochi.2013.11.020

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence

Di Leva FS, Zizza P, Cingolani C, D'Angelo C, Pagano B, Amato J, Salvati E, Sissi C, Pinato O, Marinelli L, Cavalli A, Cosconati S, Novellino E, Randazzo A, Biroccio A.

J Med Chem

2013

22/11/13

10.1021/jm401185b

Structure and stability insights into tumour suppressor p53 evolutionary related proteins

Pagano B, Jama A, Martinez P, Akanho E, Bui TT, Drake AF, Fraternali F, Nikolova PV.

PLoS One

2013

15/10/13

10.1371/journal.pone.0076014

PNA as a potential modulator of COL7A1 gene expression in dominant dystrophic epidermolysis bullosa: a physico-chemical study

Amato J, Stellato MI, Pizzo E, Petraccone L, Oliviero G, Borbone N, Piccialli G, Orecchia A, Bellei B, Castiglia D, Giancola C.

Mol Biosyst

2013

15/10/13

10.1039/c3mb70283a

Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer

De Tito S, Morvan F, Meyer A, Vasseur JJ, Cummaro A, Petraccone L, Pagano B, Novellino E, Randazzo A, Giancola C, Montesarchio D.

Bioconjug Chem

2013

08/10/13

10.1021/bc400352s

G-quadruplex unfolding in higher-order DNA structures

Fotticchia I, Giancola C, Petraccone L.

Chem Commun (Camb)

2013

10/09/13

10.1039/c3cc44560g

Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose

D'Errico S, Oliviero G, Borbone N, Amato J, Piccialli V, Varra M, Mayol L, Piccialli G.

Molecules

2013

09/08/13

10.3390/molecules18089420

Use of NMR in profiling of cocaine seizures

Pagano B, Lauri I, De Tito S, Persico G, Chini MG, Malmendal A, Novellino E, Randazzo A.

Forensic Sci Int

2013

30/07/13

10.1016/j.forsciint.2013.04.028

Application of "magnetic tongue" to the sensory evaluation of extra virgin olive oil

Lauri I, Pagano B, Malmendal A, Sacchi R, Novellino E, Randazzo A.

Food Chem

2013

23/05/13

10.1016/j.foodchem.2012.10.135

Production of enniatins A, A1, B, B1, B4, J1 by Fusarium tricinctum in solid corn culture: structural analysis and effects on mitochondrial respiration

Cuomo V, Randazzo A, Meca G, Moretti A, Cascone A, Eriksson O, Novellino E, Ritieni A.

Food Chem

2013

23/05/13

10.1016/j.foodchem.2012.10.136

Enantiomeric selection properties of β-homoDNA: enhanced pairing for heterochiral complexes

D'Alonzo D, Amato J, Schepers G, Froeyen M, Van Aerschot A, Herdewijn P, Guaragna A.

Angew Chem Int Ed Engl

2013

15/05/13

10.1002/anie.201301659

Aminosilane functionalizations of mesoporous oxidized silicon for oligonucleotide synthesis and detection

De Stefano L, Oliviero G, Amato J, Borbone N, Piccialli G, Mayol L, Rendina I, Terracciano M, Rea I.

J R Soc Interface

2013

29/03/13

10.1098/rsif.2013.0160

Differential scanning calorimetry to investigate G-quadruplexes structural stability

Pagano B, Randazzo A, Fotticchia I, Novellino E, Petraccone L, Giancola C.

Methods

2013

19/03/13

10.1016/j.ymeth.2013.02.018

The G-triplex DNA

Limongelli V, De Tito S, Cerofolini L, Fragai M, Pagano B, Trotta R, Cosconati S, Marinelli L, Novellino E, Bertini I, Randazzo A, Luchinat C, Parrinello M.

Angew Chem Int Ed Engl

2013

22/01/13

10.1002/anie.201206522

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification

Borbone N, Bucci M, Oliviero G, Morelli E, Amato J, D'Atri V, D'Errico S, Vellecco V, Cirino G, Piccialli G, Fattorusso C, Varra M, Mayol L, Persico M, Scuotto M.

J Med Chem

2012

07/11/12

10.1021/jm301414f

A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue

D'Errico S, Oliviero G, Borbone N, Amato J, D'Alonzo D, Piccialli V, Mayol L, Piccialli G.

Molecules

2012

06/11/12

10.3390/molecules171113036

Cross-talk between prion protein and quadruplex-forming nucleic acids: a dynamic complex formation

Cavaliere P, Pagano B, Granata V, Prigent S, Rezaei H, Giancola C, Zagari A.

Nucleic Acids Res

2013

30/10/12

10.1093/nar/gks970

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death

Cosconati S, Rizzo A, Trotta R, Pagano B, Iachettini S, De Tito S, Lauri I, Fotticchia I, Giustiniano M, Marinelli L, Giancola C, Novellino E, Biroccio A, Randazzo A.

J Med Chem

2012

13/10/12

10.1021/jm301019w

The abasic site lesions in the human telomeric sequence d[TA(G(3)T(2)A)(3)G(3)]: a thermodynamic point of view

Virgilio A, Petraccone L, Esposito V, Citarella G, Giancola C, Galeone A.

Biochim Biophys Acta

2012

25/09/12

10.1016/j.bbagen.2012.09.011

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

D'Atri V, Oliviero G, Amato J, Borbone N, D'Errico S, Mayol L, Piccialli V, Haider S, Hoorelbeke B, Balzarini J, Piccialli G.

Chem Commun (Camb)

2012

18/08/12

10.1039/c2cc34399a

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

D'Errico S, Oliviero G, Amato J, Borbone N, Cerullo V, Hemminki A, Piccialli V, Zaccaria S, Mayol L, Piccialli G.

Chem Commun (Camb)

2012

10/08/12

10.1039/c2cc33511e

Energetics of ligand binding to G-quadruplexes

Giancola C, Pagano B.

Top Curr Chem

2013

02/08/12

10.1007/128_2012_347

Circular dichroism of quadruplex structures

Randazzo A, Spada GP, da Silva MW.

Top Curr Chem

2013

04/07/12

10.1007/128_2012_331

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F.

Nucleic Acids Res

2012

07/06/12

10.1093/nar/gks512

Studying the effect of crowding and dehydration on DNA G-quadruplexes

Petraccone L, Pagano B, Giancola C.

Methods

2012

13/03/12

10.1016/j.ymeth.2012.02.011

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders

Pagano B, Cosconati S, Gabelica V, Petraccone L, De Tito S, Marinelli L, La Pietra V, di Leva FS, Lauri I, Trotta R, Novellino E, Giancola C, Randazzo A.

Curr Pharm Des

2012

02/03/12

10.2174/138161212799958332

G-quadruplexes from human telomeric DNA: how many conformations in PEG containing solutions?

Petraccone L, Malafronte A, Amato J, Giancola C.

J Phys Chem B

2012

25/01/12

10.1021/jp209170v

Structure and stability of higher-order human telomeric quadruplexes

Petraccone L, Spink C, Trent JO, Garbett NC, Mekmaysy CS, Giancola C, Chaires JB.

J Am Chem Soc

2011

16/11/11

10.1021/ja209192a

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

Peduto A, Pagano B, Petronzi C, Massa A, Esposito V, Virgilio A, Paduano F, Trapasso F, Fiorito F, Florio S, Giancola C, Galeone A, Filosa R.

Bioorg Med Chem

2011

28/09/11

10.1016/j.bmc.2011.08.062

NMR spectrometers as "magnetic tongues": prediction of sensory descriptors in canned tomatoes

Malmendal A, Amoresano C, Trotta R, Lauri I, De Tito S, Novellino E, Randazzo A.

J Agric Food Chem

2011

28/09/11

10.1021/jf203803q

Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose

D'Errico S, Oliviero G, Borbone N, Amato J, Piccialli V, Varra M, Mayol L, Piccialli G.

Molecules

2011

23/09/11

10.3390/molecules16098110

Molecular dynamics study of the conformational stability of esterase 2 from Alicyclobacillus acidocaldarius

Pagano B, Del Vecchio P, Mattia CA, Graziano G.

Int J Biol Macromol

2011

20/09/11

10.1016/j.ijbiomac.2011.09.002

Topological characterization of nucleic acid G-quadruplexes by UV absorption and circular dichroism

Karsisiotis AI, Hessari NM, Novellino E, Spada GP, Randazzo A, Webba da Silva M.

Angew Chem Int Ed Engl

2011

20/09/11

10.1002/anie.201105193

Solid-phase synthesis and pharmacological evaluation of novel nucleoside-tethered dinuclear platinum(II) complexes

D'Errico S, Oliviero G, Piccialli V, Amato J, Borbone N, D'Atri V, D'Alessio F, Di Noto R, Ruffo F, Salvatore F, Piccialli G.

Bioorg Med Chem Lett

2011

23/08/11

10.1016/j.bmcl.2011.07.104

Label-free probing of G-quadruplex formation by surface-enhanced Raman scattering

Rusciano G, De Luca AC, Pesce G, Sasso A, Oliviero G, Amato J, Borbone N, D'Errico S, Piccialli V, Piccialli G, Mayol L.

Anal Chem

2011

26/07/11

10.1021/ac201783h

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads

Borbone N, Amato J, Oliviero G, D'Atri V, Gabelica V, De Pauw E, Piccialli G, Mayol L.

Nucleic Acids Res

2011

01/07/11

10.1093/nar/gkr489

Thrombin-aptamer recognition: a revealed ambiguity

Russo Krauss I, Merlino A, Giancola C, Randazzo A, Mazzarella L, Sica F.

Nucleic Acids Res

2011

01/07/11

10.1093/nar/gkr522

Synthesis of a dibromoperylene phosphoramidite building block and its incorporation at the 5' end of a G-quadruplex forming oligonucleotide: spectroscopic properties and structural studies of the resulting dibromoperylene conjugate

Franceschin M, Borbone N, Oliviero G, Casagrande V, Scuotto M, Coppola T, Borioni S, Mayol L, Ortaggi G, Bianco A, Amato J, Varra M.

Bioconjug Chem

2011

22/06/11

10.1021/bc100526q

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies

Trotta R, De Tito S, Lauri I, La Pietra V, Marinelli L, Cosconati S, Martino L, Conte MR, Mayol L, Novellino E, Randazzo A.

Biochimie

2011

11/06/11

10.1016/j.biochi.2011.05.021

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies

Petraccone L, Fotticchia I, Cummaro A, Pagano B, Ginnari-Satriani L, Haider S, Randazzo A, Novellino E, Neidle S, Giancola C.

Biochimie

2011

07/06/11

10.1016/j.biochi.2011.05.017

Binding properties of human telomeric quadruplex multimers: a new route for drug design

Cummaro A, Fotticchia I, Franceschin M, Giancola C, Petraccone L.

Biochimie

2011

30/04/11

10.1016/j.biochi.2011.04.005

Targeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences

Amato J, Pagano B, Borbone N, Oliviero G, Gabelica V, Pauw ED, D'Errico S, Piccialli V, Varra M, Giancola C, Piccialli G, Mayol L.

Bioconjug Chem

2011

18/03/11

10.1021/bc100444v

Structure-cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants

Giancola C, Ercole C, Fotticchia I, Spadaccini R, Pizzo E, D'Alessio G, Picone D.

FEBS J

2011

03/12/10

10.1111/j.1742-4658.2010.07937.x

In silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activation

Autore F, Pagano B, Fornili A, Rittinger K, Fraternali F.

Biophys J

2010

30/11/10

10.1016/j.bpj.2010.09.008

A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish

Pizzo E, Merlino A, Turano M, Russo Krauss I, Coscia F, Zanfardino A, Varcamonti M, Furia A, Giancola C, Mazzarella L, Sica F, D'Alessio G.

Biochem J

2011

06/11/10

10.1042/BJ20100892

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

Oliviero G, Amato J, Borbone N, D'Errico S, Galeone A, Mayol L, Haider S, Olubiyi O, Hoorelbeke B, Balzarini J, Piccialli G.

Chem Commun (Camb)

2010

26/10/10

10.1039/c0cc02866e

Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4)

Pagano B, Fotticchia I, De Tito S, Mattia CA, Mayol L, Novellino E, Randazzo A, Giancola C.

J Nucleic Acids

2010

21/08/10

10.4061/2010/247137

Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer

Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F.

Acta Crystallogr Sect F Struct Biol Cryst Commun

2010

10/08/10

10.1107/S1744309110024632

A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures

Masiero S, Trotta R, Pieraccini S, De Tito S, Perone R, Randazzo A, Spada GP.

Org Biomol Chem

2010

05/05/10

10.1039/c003428b

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle

Cosconati S, Marinelli L, Trotta R, Virno A, De Tito S, Romagnoli R, Pagano B, Limongelli V, Giancola C, Baraldi PG, Mayol L, Novellino E, Randazzo A.

J Am Chem Soc

2010

17/04/10

10.1021/ja1003872

Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights

Merabet A, Houlleberghs H, Maclagan K, Akanho E, Bui TT, Pagano B, Drake AF, Fraternali F, Nikolova PV.

Biochem J

2010

02/02/10

10.1042/BJ20091888

Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures

Esposito V, Martino L, Citarella G, Virgilio A, Mayol L, Giancola C, Galeone A.

Nucleic Acids Res

2010

23/12/09

10.1093/nar/gkp1087

Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase

Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G.

FEBS Lett

2010

17/11/09

10.1016/j.febslet.2009.11.022

Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders

Cosconati S, Marinelli L, Trotta R, Virno A, Mayol L, Novellino E, Olson AJ, Randazzo A.

J Am Chem Soc

2009

28/10/09

10.1021/ja9063662

Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes

Martino L, Pagano B, Fotticchia I, Neidle S, Giancola C.

J Phys Chem B

2009

15/10/09

10.1021/jp9066394

Competitive binding exchange between alkali metal ions (K+, Rb+, and Cs+) and Na+ ions bound to the dimeric quadruplex [d(G4T4G4)]2: a 23Na and 1H NMR study

Cesare Marincola F, Virno A, Randazzo A, Mocci F, Saba G, Lai A.

Magn Reson Chem

2009

17/09/09

10.1002/mrc.2509

Applications of isothermal titration calorimetry in biophysical studies of G-quadruplexes

Pagano B, Mattia CA, Giancola C.

Int J Mol Sci

2009

11/09/09

10.3390/ijms10072935

The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity

Martino L, He Y, Hands-Taylor KL, Valentine ER, Kelly G, Giancola C, Conte MR.

FEBS J

2009

04/08/09

10.1111/j.1742-4658.2009.07159.x

Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability

Oliviero G, Borbone N, Amato J, D'Errico S, Galeone A, Piccialli G, Varra M, Mayol L.

Biopolymers

2009

04/02/09

10.1002/bip.21153

Hybridization of short complementary PNAs to G-quadruplex forming oligonucleotides: An electrospray mass spectrometry study

Amato J, Oliviero G, De Pauw E, Gabelica V.

Biopolymers

2009

10/12/08

10.1002/bip.21124

Differential binding of human immunoagents and Herceptin to the ErbB2 receptor

Troise F, Cafaro V, Giancola C, D'Alessio G, De Lorenzo C.

FEBS J

2008

18/09/08

10.1111/j.1742-4658.2008.06625.x

Ligand binding to tetra-end-linked (TGGGGT)4 G-quadruplexes: an electrospray mass spectroscopy study

Amato J, Oliviero G, Borbone N, D'Errico S, Piccialli G, Mailliet P, Rosu F, De Pauw E, Gabelica V.

Nucleic Acids Symp Ser (Oxf)

2008

09/09/08

10.1093/nass/nrn084

A short C-rich PNA fragment capable to form novel G-quadruplex-PNA complexes

Amato J, Gabelica V, Borbone N, Rosu F, De Pauw E, Oliviero G, Piccialli G, Mayol L.

Nucleic Acids Symp Ser (Oxf)

2008

09/09/08

10.1093/nass/nrn085

Synthesis of N-1-alkyl analogues of cyclic inosine diphosphate ribose (cIDPR) by a new solid phase approach

Oliviero G, D'Errico S, Borbone N, Amato J, Piccialli V, Varra M, Piccialli G, Mayol L.

Nucleic Acids Symp Ser (Oxf)

2008

09/09/08

10.1093/nass/nrn290

Stability and cations coordination of DNA and RNA 14-mer G-quadruplexes: a multiscale computational approach

Pagano B, Mattia CA, Cavallo L, Uesugi S, Giancola C, Fraternali F.

J Phys Chem B

2008

05/09/08

10.1021/jp804036j

Targeting DNA quadruplexes with distamycin A and its derivatives: an ITC and NMR study

Pagano B, Virno A, Mattia CA, Mayol L, Randazzo A, Giancola C.

Biochimie

2008

19/04/08

10.1016/j.biochi.2008.03.006

A further contribution to the extreme variability of quadruplex structures from oligodeoxyribonucleotides containing inversion of polarity sites in the G-tract

Galeone A, Mayol L, Virgilio A, Virno A, Randazzo A.

Mol Biosyst

2008

17/04/08

10.1039/b718778e

Ribonucleases with angiogenic and bactericidal activities from the Atlantic salmon

Pizzo E, Varcamonti M, Di Maro A, Zanfardino A, Giancola C, D'Alessio G.

FEBS J

2008

19/02/08

10.1111/j.1742-4658.2008.06289.x

Synthesis, biophysical characterization, and anti-HIV activity of glyco-conjugated G-quadruplex-forming oligonucleotides

D'Onofrio J, Petraccone L, Martino L, Di Fabio G, Iadonisi A, Balzarini J, Giancola C, Montesarchio D.

Bioconjug Chem

2008

08/02/08

10.1021/bc7003395

Thermodynamic analysis of quadruplex DNA-drug interaction

Pagano B, Mattia CA, Virno A, Randazzo A, Mayol L, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701499069

Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues

Oliviero G, Amato J, D'Errico S, Borbone N, Piccialli G, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701506608

Optical tweezers as a probe for oligodeoxyribonucleotide structuration

Borbone N, Oliviero G, Amato J, Piccialli G, Mayol L, Miccio L, Pescen G, Sasso A.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701530541

Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

Borbone N, Oliviero G, Amato J, D'Errico S, Galeone A, Piccialli G, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701528172

Synthesis of a new ribose modified analogue of cyclic inosine diphosphate ribose

Oliviero G, Borbone N, Amato J, D'Errico S, Piccialli G, Varra M, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701530699

Effect of the incorporation of 2'-deoxy-8-(hydroxyl)adenosine on the stability of quadruplexes formed by modified human telomeric DNA

Petraccone L, Duro I, Erra E, Randazzo A, Virno A, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701490597

Biophysical properties of quadruplexes containing two or three 8-bromodeoxyguanosine residues

Petraccone L, Duro I, Randazzo A, Virno A, Mayol L, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2007

11/12/07

10.1080/15257770701490589

Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4

Martino L, Virno A, Pagano B, Virgilio A, Di Micco S, Galeone A, Giancola C, Bifulco G, Mayol L, Randazzo A.

J Am Chem Soc

2007

07/12/07

10.1021/ja075710k

Structural insight into the hTERT intron 6 sequence d(GGGGTGAAAGGGG) from 1H-NMR study

Virno A, Mayol L, Ramos A, Fraternali F, Pagano B, Randazzo A.

Nucleosides Nucleotides Nucleic Acids

2007

07/12/07

10.1080/15257770701521854

Molecular modelling studies of four stranded quadruplexes containing a 3'-3' or 5'-5' inversion of polarity site

Virno A, Zaccaria F, Virgilio A, Esposito V, Galeone A, Mayol L, Randazzo A.

Nucleosides Nucleotides Nucleic Acids

2007

07/12/07

10.1080/15257770701521888

Effect of rubidium and cesium ions on the dimeric quaduplex formed by the Oxytricha nova telomeric repeat oligonucleotide d(GGGGTTTTGGGG)

Marincola FC, Virno A, Randazzo A, Lai A.

Nucleosides Nucleotides Nucleic Acids

2007

07/12/07

10.1080/15257770701521821

Relative stereochemistry of a diterpene from Salvia cinnabarina

Bisio A, Pagano B, Romussi A, Bruno O, De Tommasi N, Romussi G, Mattia CA.

Molecules

2007

06/11/07

10.3390/12102279

Stability and binding properties of a modified thrombin binding aptamer

Pagano B, Martino L, Randazzo A, Giancola C.

Biophys J

2008

25/09/07

10.1529/biophysj.107.117382

Conformational stability and DNA binding energetics of the rat thyroid transcription factor 1 homeodomain

Del Vecchio P, Carullo P, Barone G, Pagano B, Graziano G, Iannetti A, Acquaviva R, Leonardi A, Formisano S.

Proteins

2008

31/08/07

10.1002/prot.21552

A novel thrombin binding aptamer containing a G-LNA residue

Virno A, Randazzo A, Giancola C, Bucci M, Cirino G, Mayol L.

Bioorg Med Chem

2007

26/06/07

10.1016/j.bmc.2007.06.008

5'-Modified G-quadruplex forming oligonucleotides endowed with anti-HIV activity: synthesis and biophysical properties

D'Onofrio J, Petraccone L, Erra E, Martino L, Fabio GD, Napoli LD, Giancola C, Montesarchio D.

Bioconjug Chem

2007

16/06/07

10.1021/bc070062f

A new modified thrombin binding aptamer containing a 5'-5' inversion of polarity site

Martino L, Virno A, Randazzo A, Virgilio A, Esposito V, Giancola C, Bucci M, Cirino G, Mayol L.

Nucleic Acids Res

2006

06/12/06

10.1093/nar/gkl915

Physico-chemical analysis of G-quadruplex containing bunch-oligonucleotides

Petraccone L, Martino L, Duro I, Oliviero G, Borbone N, Piccialli G, Giancola C.

Int J Biol Macromol

2007

19/09/06

10.1016/j.ijbiomac.2006.07.013

Energetic aspects of locked nucleic acids quadruplex association and dissociation

Petraccone L, Erra E, Randazzo A, Giancola C.

Biopolymers

2006

01/09/06

10.1002/bip.20591

Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides

Oliviero G, Amato J, Borbone N, Galeone A, Petraccone L, Varra M, Piccialli G, Mayol L.

Bioconjug Chem

2006

20/07/06

10.1021/bc060009b

Cyclic phosphate-linked oligosaccharides: synthesis and conformational behavior of novel cyclic oligosaccharide analogues

Di Fabio G, Randazzo A, D'Onofrio J, Ausín C, Pedroso E, Grandas A, De Napoli L, Montesarchio D.

J Org Chem

2006

22/04/06

10.1021/jo0600757

Thermodynamics and kinetics of PNA-DNA quadruplex-forming chimeras

Petraccone L, Pagano B, Esposito V, Randazzo A, Piccialli G, Barone G, Mattia CA, Giancola C.

J Am Chem Soc

2005

17/11/05

10.1021/ja0545923

8-methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structures

Virgilio A, Esposito V, Randazzo A, Mayol L, Galeone A.

Nucleic Acids Res

2005

01/11/05

10.1093/nar/gki924

Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides

Oliviero G, Amato J, Borbone N, Galeone A, Varra M, Piccialli G, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060048

Synthesis of a new N-9 ribityl analogue of cyclic inosine diphosphate ribose (cIDPR) as a mimic of cyclic ADP ribose (cADPR)

Oliviero G, Amato J, Varra M, Piccialli G, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060041

Interaction of porphyrin with G-quadruplex structures

Erra E, Petraccone L, Esposito V, Randazzo A, Mayol L, Ladbury J, Barone G, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060070

Relative stability of quadruplexes containing different number of G-tetrads

Petraccone L, Erra E, Duro I, Esposito V, Randazzo A, Mayol L, Mattia CA, Barone G, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060080

Molecular modeling studies of a parallel stranded quadruplexes containing a 8-bromoadenosine

Esposito V, Randazzo A, Petraccone L, Giancola C, Erra E, Virgilio A, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060265

Structural studies on LNA quadruplexes

Randazzo A, Esposito V, Ohlenschläger O, Ramachandran R, Virgilio A, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060279

Effects of a 8-oxoadenosine incorporation on quadruplex structures: thermal stabilities and structural studies

Esposito V, Randazzo A, Virgilio A, Cozzuto L, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200060156

Synthesis and structural study of quadruplex structures containing 2'-deoxy-8-methyladenosine

Randazzo A, Esposito V, Galeone A, Varra M, Virgilio A, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2005

27/10/05

10.1081/ncn-200061802

Synthesis and characterization of DNA quadruplexes containing T-tetrads formed by bunch-oligonucleotides

Oliviero G, Amato J, Borbone N, Galeone A, Varra M, Piccialli G, Mayol L.

Biopolymers

2006

20/10/05

10.1002/bip.20399

A new class of DNA quadruplexes formed by oligodeoxyribonucleotides containing a 3'-3' or 5'-5' inversion of polarity site

Esposito V, Virgilio A, Randazzo A, Galeone A, Mayol L.

Chem Commun (Camb)

2005

03/08/05

10.1039/b504455c

Preparation and characterization of geodin. A betagamma-crystallin-type protein from a sponge

Giancola C, Pizzo E, Di Maro A, Cubellis MV, D'Alessio G.

FEBS J

2005

05/02/05

10.1111/j.1742-4658.2004.04536.x

Effects of 8-methyl-2'-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides

Virgilio A, Esposito V, Randazzo A, Mayol L, Galeone A.

Bioorg Med Chem

2005

27/01/05

10.1016/j.bmc.2004.11.037

Biophysical properties of quadruple helices of modified human telomeric DNA

Petraccone L, Erra E, Esposito V, Randazzo A, Galeone A, Barone G, Giancola C.

Biopolymers

2005

23/12/04

10.1002/bip.20189

Linkage of proton binding to the thermal dissociation of triple helix complex

Petraccone L, Erra E, Mattia CA, Fedullo V, Barone G, Giancola C.

Biophys Chem

2004

30/06/04

10.1016/j.bpc.2004.01.004

NMR solution structure of a parallel LNA quadruplex

Randazzo A, Esposito V, Ohlenschläger O, Ramachandran R, Mayola L.

Nucleic Acids Res

2004

08/06/04

10.1093/nar/gkh629

Stability and structure of telomeric DNA sequences forming quadruplexes containing four G-tetrads with different topological arrangements

Petraccone L, Erra E, Esposito V, Randazzo A, Mayol L, Nasti L, Barone G, Giancola C.

Biochemistry

2004

21/04/04

10.1021/bi0300985

Structural study of four-stranded quadruplex structures containing 2'-deoxy-8-(propyn-1-yl)adenosine

Esposito V, Randazzo A, Galeone A, Varra M, Mayol L.

Bioorg Med Chem

2004

26/02/04

10.1016/j.bmc.2003.11.019

Effects of an 8-bromodeoxyguanosine incorporation on the parallel quadruplex structure [d(TGGGT)]4

Esposito V, Randazzo A, Piccialli G, Petraccone L, Giancola C, Mayol L.

Org Biomol Chem

2004

30/01/04

10.1039/b314672c

1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine

Petraccone L, Erra E, Nasti L, Galeone A, Randazzo A, Esposito V, Mayol L, Barone G, Giancola C.

Nucleosides Nucleotides Nucleic Acids

2003

21/10/03

10.1081/NCN-120023111

PNA-DNA chimeras forming quadruplex structures

Esposito V, Galeone A, Mayol L, Messere A, Piccialli G, Randazzo A.

Nucleosides Nucleotides Nucleic Acids

2003

21/10/03

10.1081/NCN-120023112

Petrosaspongiolide M reduces morphine withdrawal in vitro

Capasso A, Casapullo A, Randazzo A, Gomez-Paloma L.

Life Sci

2003

29/05/03

10.1016/s0024-3205(03)00319-9

Inhibition of the NF-kappaB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M

Posadas I, Terencio MC, Randazzo A, Gomez-Paloma L, Payá M, Alcaraz MJ.

Biochem Pharmacol

2003

12/03/03

10.1016/s0006-2952(02)01659-3

Configuration assignment in small organic molecules via residual dipolar couplings

Mangoni A, Esposito V, Randazzo A.

Chem Commun (Camb)

2003

04/03/03

10.1039/b210454g

Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex

Petraccone L, Erra E, Nasti L, Galeone A, Randazzo A, Mayol L, Barone G, Giancola C.

Int J Biol Macromol

2003

06/02/03

10.1016/s0141-8130(02)00073-9

Interaction of distamycin A and netropsin with quadruplex and duplex structures: a comparative 1H-NMR study

Randazzo A, Galeone A, Esposito V, Varra M, Mayol L.

Nucleosides Nucleotides Nucleic Acids

2002

18/12/02

10.1081/NCN-120015067

Engineering the refolding pathway and the quaternary structure of seminal ribonuclease by newly introduced disulfide bridges

Russo A, Antignani A, Giancola C, D'Alessio G.

J Biol Chem

2002

16/10/02

10.1074/jbc.M207141200

Molecular basis of phospholipase A2 inhibition by petrosaspongiolide M

Dal Piaz F, Casapullo A, Randazzo A, Riccio R, Pucci P, Marino G, Gomez-Paloma L.

Chembiochem

2002

27/09/02

10.1002/1439-7633(20020703)3:7<664::AID-CBIC664>3.0.CO;2-9